Werner Protein Protects Nonproliferating Cells from Oxidative DNA Damage

Werner syndrome, caused by mutations of the WRN gene, mimics many changes of normal aging. Although roles for WRN protein in DNA replication, recombination, and telomere maintenance have been suggested, the pathology of rapidly dividing cells is not a feature of Werner syndrome. To identify cellular...

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Bibliographic Details
Main Authors: Szekely, Anna M., Bleichert, Franziska, Nümann, Astrid, Van Komen, Stephen, Manasanch, Elisabeth, Ben Nasr, Abdelhakim, Canaan, Allon, Weissman, Sherman M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1291253/
https://ncbi.nlm.nih.gov/pubmed/16287861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.23.10492-10506.2005
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