Eukaryotic Translation Initiation Factor 4E Availability Controls the Switch between Cap-Dependent and Internal Ribosomal Entry Site-Mediated Translation

Translation of m(7)G-capped cellular mRNAs is initiated by recruitment of ribosomes to the 5′ end of mRNAs via eukaryotic translation initiation factor 4F (eIF4F), a heterotrimeric complex comprised of a cap-binding subunit (eIF4E) and an RNA helicase (eIF4A) bridged by a scaffolding molecule (eIF4G...

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Autors principals: Svitkin, Yuri V., Herdy, Barbara, Costa-Mattioli, Mauro, Gingras, Anne-Claude, Raught, Brian, Sonenberg, Nahum
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1291233/
https://ncbi.nlm.nih.gov/pubmed/16287867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.23.10556-10565.2005
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