Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex

The heterodimeric nuclear cap-binding complex (CBC) binds to the 5′ cap structure of RNAs in the nucleus and plays a central role in their diverse maturation steps. We describe the crystal structure at 2.1 Å resolution of human CBC bound to an m(7)GpppG cap analogue. Comparison with the structure of...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Mazza, Catherine, Segref, Alexandra, Mattaj, Iain W., Cusack, Stephen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2002
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129070/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12374755/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf538
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