Transcription elongation factor hSPT5 stimulates mRNA capping

RNA polymerase II nascent transcripts are capped during pausing before elongation. Here we report that hSPT5, the human homolog of yeast elongation factor SPT5, interacts directly with the capping enzyme. hSPT5 stimulated capping enzyme guanylylation and mRNA capping by severalfold. Although RNA 5′-...

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Main Authors: Wen, Yingxia, Shatkin, Aaron J.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 1999
主題:
Research Communication
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC316881/
https://ncbi.nlm.nih.gov/pubmed/10421630
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