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Transcription elongation factor hSPT5 stimulates mRNA capping

RNA polymerase II nascent transcripts are capped during pausing before elongation. Here we report that hSPT5, the human homolog of yeast elongation factor SPT5, interacts directly with the capping enzyme. hSPT5 stimulated capping enzyme guanylylation and mRNA capping by severalfold. Although RNA 5′-...

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書誌詳細
出版年:Genes Dev
主要な著者: Wen, Yingxia, Shatkin, Aaron J.
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 1999
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316881/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10421630/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.14.1774
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