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Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1

Members of the Inhibitor of Apoptosis Protein (IAP) family are essential for cell survival in Drosophila and appear to neutralize the cell death machinery by binding to and ubiquitylating pro-apoptotic caspases. Cell death is triggered when ‘Reaper-like’ proteins bind to IAPs and liberate caspases f...

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Udgivet i:EMBO J
Principais autores: Tenev, Tencho, Zachariou, Anna, Wilson, Rebecca, Paul, Angela, Meier, Pascal
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC129052/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12356728/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf530
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