Akt/Protein Kinase B Activation by Adenovirus Vectors Contributes to NFκB-Dependent CXCL10 Expression

In gene therapy, the innate immune system is a significant barrier to the effective application of adenovirus (Ad) vectors. In kidney epithelium-derived (REC) cells, serotype 5 Ad vectors induce the expression of the chemokine CXCL10 (IP-10), a response that is dependent on NFκB. Compared to the par...

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Detalhes bibliográficos
Main Authors: Liu, Qiang, White, Lindsay R., Clark, Sharon A., Heffner, Daniel J., Winston, Brent W., Tibbles, Lee Anne, Muruve, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1287576/
https://ncbi.nlm.nih.gov/pubmed/16282450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.23.14507-14515.2005
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