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NF-κB promotes leaky expression of adenovirus genes in a replication-incompetent adenovirus vector
The replication-incompetent adenovirus (Ad) vector is one of the most promising vectors for gene therapy; however, systemic administration of Ad vectors results in severe hepatotoxicities, partly due to the leaky expression of Ad genes in the liver. Here we show that nuclear factor-kappa B (NF-κB) m...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4728692/ https://ncbi.nlm.nih.gov/pubmed/26814140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19922 |
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