Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome

Leaky expression of adenovirus (Ad) genes occurs following transduction with a conventional replication-incompetent Ad vector, leading to an induction of cellular immunity against Ad proteins and Ad protein-induced toxicity, especially in the late phase following administration. To suppress the leak...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Shimizu, Kahori, Sakurai, Fuminori, Tomita, Kyoko, Nagamoto, Yasuhito, Nakamura, Shin-ichiro, Katayama, Kazufumi, Tachibana, Masashi, Kawabata, Kenji, Mizuguchi, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362365/
https://ncbi.nlm.nih.gov/pubmed/26015975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2014.35
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