Interaction of Avilamycin with Ribosomes and Resistance Caused by Mutations in 23S rRNA

The antibiotic growth promoter avilamycin inhibits protein synthesis by binding to bacterial ribosomes. Here the binding site is further characterized on Escherichia coli ribosomes. The drug interacts with domain V of 23S rRNA, giving a chemical footprint at nucleotides A2482 and A2534. Selection of...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Kofoed, Christine B., Vester, Birte
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Mechanisms of Action: Physiological Effects
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128742/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12384333/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.11.3339-3342.2002
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