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Interaction of Avilamycin with Ribosomes and Resistance Caused by Mutations in 23S rRNA

The antibiotic growth promoter avilamycin inhibits protein synthesis by binding to bacterial ribosomes. Here the binding site is further characterized on Escherichia coli ribosomes. The drug interacts with domain V of 23S rRNA, giving a chemical footprint at nucleotides A2482 and A2534. Selection of...

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Bibliografski detalji
Glavni autori: Kofoed, Christine B., Vester, Birte
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC128742/
https://ncbi.nlm.nih.gov/pubmed/12384333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.11.3339-3342.2002
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