Molecular Mechanisms of Resistance to Human Immunodeficiency Virus Type 1 with Reverse Transcriptase Mutations K65R and K65R+M184V and Their Effects on Enzyme Function and Viral Replication Capacity

Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) resistance mutations K65R and M184V result in changes in susceptibility to several nucleoside and nucleotide RT inhibitors. K65R-containing viruses showed decreases in susceptibility to tenofovir, didanosine (ddI), abacavir, and...

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Bibliographic Details
Main Authors: White, Kirsten L., Margot, Nicolas A., Wrin, Terri, Petropoulos, Christos J., Miller, Michael D., Naeger, Lisa K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC128721/
https://ncbi.nlm.nih.gov/pubmed/12384348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.11.3437-3446.2002
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