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M-CSF mediates TNF-induced inflammatory osteolysis

TNF-α is the dominant cytokine in inflammatory osteolysis. Using mice whose BM stromal cells and osteoclast precursors are chimeric for the presence of TNF receptors, we found that both cell types mediated the cytokine’s osteoclastogenic properties. The greater contribution was made, however, by str...

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Detalhes bibliográficos
Main Authors: Kitaura, Hideki, Zhou, Ping, Kim, Hyun-Ju, Novack, Deborah V., Ross, F. Patrick, Teitelbaum, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283943/
https://ncbi.nlm.nih.gov/pubmed/16294221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26132
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