IL-1 mediates TNF-induced osteoclastogenesis

TNF-induced receptor activator NF-κB ligand (RANKL) synthesis by bone marrow stromal cells is a fundamental component of inflammatory osteolysis. We found that this process was abolished by IL-1 receptor antagonist (IL-1Ra) or in stromal cells derived from type I IL-1 receptor–deficient (IL-1RI–defi...

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Hlavní autoři: Wei, Shi, Kitaura, Hideki, Zhou, Ping, Ross, F. Patrick, Teitelbaum, Steven L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2005
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC544608/
https://ncbi.nlm.nih.gov/pubmed/15668736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200523394
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