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M-CSF mediates TNF-induced inflammatory osteolysis

TNF-α is the dominant cytokine in inflammatory osteolysis. Using mice whose BM stromal cells and osteoclast precursors are chimeric for the presence of TNF receptors, we found that both cell types mediated the cytokine’s osteoclastogenic properties. The greater contribution was made, however, by str...

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Autors principals: Kitaura, Hideki, Zhou, Ping, Kim, Hyun-Ju, Novack, Deborah V., Ross, F. Patrick, Teitelbaum, Steven L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283943/
https://ncbi.nlm.nih.gov/pubmed/16294221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI26132
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