TNF-induced structural joint damage is mediated by IL-1

Blocking TNF effectively inhibits inflammation and structural damage in human rheumatoid arthritis (RA). However, so far it is unclear whether the effect of TNF is a direct one or indirect on up-regulation of other mediators. IL-1 may be one of these candidates because it has a central role in anima...

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Detalhes bibliográficos
Main Authors: Zwerina, Jochen, Redlich, Kurt, Polzer, Karin, Joosten, Leo, Krönke, Gerhard, Distler, Joerg, Hess, Andreas, Pundt, Noreen, Pap, Thomas, Hoffmann, Oskar, Gasser, Juerg, Scheinecker, Clemens, Smolen, Josef S., van den Berg, Wim, Schett, Georg
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1913858/
https://ncbi.nlm.nih.gov/pubmed/17609389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610812104
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