Interleukin-4 Receptor α Chain and STAT6 Signaling Inhibit Gamma Interferon but Not Th2 Cytokine Expression within Schistosome Granulomas

Compared to wild-type (WT) mice, schistosome granulomas in Stat6 knockout (KO) mice lacked eosinophils and had Th1 features. Interleukin-4 (IL-4) acts through Stat6 in assisting Th2 cell development. The importance of Stat6 for Th2-cell development within schistosome granulomas had not been explored...

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Pubblicato in:	Infect Immun
Autori principali:	Metwali, Ahmed, Blum, Arthur, Elliott, David E., Weinstock, Joel V.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Fungal and Parasitic Infections
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128339/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12228294/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.10.5651-5658.2002
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