Interleukin-4 Receptor α Chain and STAT6 Signaling Inhibit Gamma Interferon but Not Th2 Cytokine Expression within Schistosome Granulomas

Compared to wild-type (WT) mice, schistosome granulomas in Stat6 knockout (KO) mice lacked eosinophils and had Th1 features. Interleukin-4 (IL-4) acts through Stat6 in assisting Th2 cell development. The importance of Stat6 for Th2-cell development within schistosome granulomas had not been explored...

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Detalhes bibliográficos
Main Authors: Metwali, Ahmed, Blum, Arthur, Elliott, David E., Weinstock, Joel V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC128339/
https://ncbi.nlm.nih.gov/pubmed/12228294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.10.5651-5658.2002
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