Impaired DNA Replication within Progenitor Cell Pools Promotes Leukemogenesis

Impaired cell cycle progression can be paradoxically associated with increased rates of malignancies. Using retroviral transduction of bone marrow progenitors followed by transplantation into mice, we demonstrate that inhibition of hematopoietic progenitor cell proliferation impairs competition, pro...

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Main Authors: Bilousova, Ganna, Marusyk, Andriy, Porter, Christopher C, Cardiff, Robert D, DeGregori, James
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2005
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283331/
https://ncbi.nlm.nih.gov/pubmed/16277552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0030401
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