Plasma Membrane Cholesterol Modulates Cellular Vacuolation Induced by the Helicobacter pylori Vacuolating Cytotoxin

The Helicobacter pylori vacuolating cytotoxin (VacA) induces the degenerative vacuolation of mammalian cells both in vitro and in vivo. Here, we demonstrate that plasma membrane cholesterol is essential for vacuolation of mammalian cells by VacA. Vacuole biogenesis in multiple cell lines was complet...

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Detalles Bibliográficos

Publicado en:	Infect Immun
Principais autores:	Patel, Hetal K., Willhite, David C., Patel, Rakhi M., Ye, Dan, Williams, Christopher L., Torres, Eric M., Marty, Kent B., MacDonald, Robert A., Blanke, Steven R.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 2002
Assuntos:	Molecular Pathogenesis
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128184/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12117919/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.8.4112-4123.2002
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