Plasma Membrane Cholesterol Modulates Cellular Vacuolation Induced by the Helicobacter pylori Vacuolating Cytotoxin

The Helicobacter pylori vacuolating cytotoxin (VacA) induces the degenerative vacuolation of mammalian cells both in vitro and in vivo. Here, we demonstrate that plasma membrane cholesterol is essential for vacuolation of mammalian cells by VacA. Vacuole biogenesis in multiple cell lines was complet...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Patel, Hetal K., Willhite, David C., Patel, Rakhi M., Ye, Dan, Williams, Christopher L., Torres, Eric M., Marty, Kent B., MacDonald, Robert A., Blanke, Steven R.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Molecular Pathogenesis
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC128184/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12117919/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.8.4112-4123.2002
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