A Class of Pantothenic Acid Analogs Inhibits Plasmodium falciparum Pantothenate Kinase and Represses the Proliferation of Malaria Parasites

The growth and proliferation of the human malaria parasite Plasmodium falciparum are dependent on the parasite's ability to obtain essential nutrients. One nutrient for which the parasite has an absolute requirement is the water-soluble vitamin pantothenic acid (vitamin B(5)). In this study, a...

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Bibliographic Details
Main Authors: Spry, Christina, Chai, Christina L. L., Kirk, Kiaran, Saliba, Kevin J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280137/
https://ncbi.nlm.nih.gov/pubmed/16251308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.11.4649-4657.2005
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