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Phase I Evaluation of ΔvirG Shigella sonnei Live, Attenuated, Oral Vaccine Strain WRSS1 in Healthy Adults

We conducted a phase I trial with healthy adults to evaluate WRSS1, a live, oral ΔvirG Shigella sonnei vaccine candidate. In a double-blind, randomized, dose-escalating fashion, inpatient volunteers received a single dose of either placebo (n = 7) or vaccine (n = 27) at 3 × 10(3) CFU (group 1), 3 ×...

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Published in:Infect Immun
Main Authors: Kotloff, Karen L., Taylor, David N., Sztein, Marcelo B., Wasserman, Steven S., Losonsky, Genevieve A., Nataro, James P., Venkatesan, Malabi, Hartman, Antoinette, Picking, William D., Katz, David E., Campbell, James D., Levine, Myron M., Hale, Thomas L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2002
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127867/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11895966/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.4.2016-2021.2002
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