Phase I Evaluation of ΔvirG Shigella sonnei Live, Attenuated, Oral Vaccine Strain WRSS1 in Healthy Adults

We conducted a phase I trial with healthy adults to evaluate WRSS1, a live, oral ΔvirG Shigella sonnei vaccine candidate. In a double-blind, randomized, dose-escalating fashion, inpatient volunteers received a single dose of either placebo (n = 7) or vaccine (n = 27) at 3 × 10(3) CFU (group 1), 3 ×...

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Bibliografske podrobnosti
Main Authors: Kotloff, Karen L., Taylor, David N., Sztein, Marcelo B., Wasserman, Steven S., Losonsky, Genevieve A., Nataro, James P., Venkatesan, Malabi, Hartman, Antoinette, Picking, William D., Katz, David E., Campbell, James D., Levine, Myron M., Hale, Thomas L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Microbial Immunity and Vaccines
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC127867/
https://ncbi.nlm.nih.gov/pubmed/11895966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.4.2016-2021.2002
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