Phase I Evaluation of ΔvirG Shigella sonnei Live, Attenuated, Oral Vaccine Strain WRSS1 in Healthy Adults

We conducted a phase I trial with healthy adults to evaluate WRSS1, a live, oral ΔvirG Shigella sonnei vaccine candidate. In a double-blind, randomized, dose-escalating fashion, inpatient volunteers received a single dose of either placebo (n = 7) or vaccine (n = 27) at 3 × 10(3) CFU (group 1), 3 ×...

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Bibliographische Detailangaben
Hauptverfasser: Kotloff, Karen L., Taylor, David N., Sztein, Marcelo B., Wasserman, Steven S., Losonsky, Genevieve A., Nataro, James P., Venkatesan, Malabi, Hartman, Antoinette, Picking, William D., Katz, David E., Campbell, James D., Levine, Myron M., Hale, Thomas L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC127867/
https://ncbi.nlm.nih.gov/pubmed/11895966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.4.2016-2021.2002
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