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Phase I Evaluation of ΔvirG Shigella sonnei Live, Attenuated, Oral Vaccine Strain WRSS1 in Healthy Adults

We conducted a phase I trial with healthy adults to evaluate WRSS1, a live, oral ΔvirG Shigella sonnei vaccine candidate. In a double-blind, randomized, dose-escalating fashion, inpatient volunteers received a single dose of either placebo (n = 7) or vaccine (n = 27) at 3 × 10(3) CFU (group 1), 3 ×...

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Publicado no:Infect Immun
Principais autores: Kotloff, Karen L., Taylor, David N., Sztein, Marcelo B., Wasserman, Steven S., Losonsky, Genevieve A., Nataro, James P., Venkatesan, Malabi, Hartman, Antoinette, Picking, William D., Katz, David E., Campbell, James D., Levine, Myron M., Hale, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2002
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127867/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11895966/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.70.4.2016-2021.2002
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