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ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
The p53 tumor suppressor is activated after DNA damage to maintain genomic stability and prevent transformation. Rapid activation of p53 by ionizing radiation is dependent on signaling by the ATM kinase. MDM2 and MDMX are important p53 regulators and logical targets for stress signals. We found that...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1276172/ https://ncbi.nlm.nih.gov/pubmed/16163388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600812 |
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