Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation

p53 plays a central role in tumor suppression. It does so by inducing anti-proliferative processes as a response to various tumor-promoting stresses. p53 is regulated by the ubiquitin ligase Mdm2. The optimal function of Mdm2 requires Daxx, which stabilizes Mdm2 through the deubiquitinase Hausp/USP7...

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Bibliografiske detaljer
Main Authors: Tang, Jun, Agrawal, Trisha, Cheng, Qian, Qu, Like, Brewer, Michael D., Chen, Jiandong, Yang, Xiaolu
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566025/
https://ncbi.nlm.nih.gov/pubmed/23405218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055813
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