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Phosphorylation of Daxx by ATM Contributes to DNA Damage-Induced p53 Activation
p53 plays a central role in tumor suppression. It does so by inducing anti-proliferative processes as a response to various tumor-promoting stresses. p53 is regulated by the ubiquitin ligase Mdm2. The optimal function of Mdm2 requires Daxx, which stabilizes Mdm2 through the deubiquitinase Hausp/USP7...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3566025/ https://ncbi.nlm.nih.gov/pubmed/23405218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055813 |
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