Importance of the Fourth Alpha-Helix within the CAP Homology Domain of Type II Topoisomerase for DNA Cleavage Site Recognition and Quinolone Action

We report that point mutations causing alteration of the fourth alpha-helix (α4-helix) of the CAP homology domain of eukaryotic (Saccharomyces cerevisiae) type II topoisomerases (Ser(740)Trp, Gln(743)Pro, and Thr(744)Pro) change the selection of type II topoisomerase-mediated DNA cleavage sites prom...

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Detalhes bibliográficos
Main Authors: Strumberg, Dirk, Nitiss, John L., Dong, Jiaowang, Walker, Jerrylaine, Nicklaus, Marc C., Kohn, Kurt W., Heddle, Jonathan G., Maxwell, Anthony, Seeber, Siegfried, Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127396/
https://ncbi.nlm.nih.gov/pubmed/12183223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.9.2735-2746.2002
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