Transport of an Antifungal Trypsin Inhibitor Isolated from Corn across the Blood-Brain Barrier

We determined whether an antifungal 14-kDa protein trypsin inhibitor isolated from corn is able to cross the blood-brain barrier. We found that it completely crossed the blood-brain barrier by means of a saturable mechanism at a rate of 0.153 μl/g · min, with about 0.082% of the intravenously inject...

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Bibliographic Details
Main Authors: Banks, William A., Niehoff, Michael L., Brown, Robert L., Chen, Zhi-Yuan, Cleveland, Thomas E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC127332/
https://ncbi.nlm.nih.gov/pubmed/12121944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.8.2633-2635.2002
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