Therapeutic Efficacies of GW471552 and GW471558, Two New Azasordarin Derivatives, against Pneumocystosis in Two Immunosuppressed-Rat Models

Two new azasordarins, GW471552 and GW471558, were studied in vivo for treatment of Pneumocystis carinii pneumonia. In the Wistar rat spontaneous pneumonia model, both azasordarins significantly reduced the number of P. carinii cysts per gram of lung homogenate when administered at 1 mg/kg of body we...

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Autores principales: Jimenez, Elena, Martínez, Antonio, Aliouat, El Moukhtar, Caballero, Jesus, Dei-Cas, Eduardo, Gargallo-Viola, Domingo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC127331/
https://ncbi.nlm.nih.gov/pubmed/12121948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.8.2648-2650.2002
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