Therapeutic Efficacies of GW471552 and GW471558, Two New Azasordarin Derivatives, against Pneumocystosis in Two Immunosuppressed-Rat Models

Two new azasordarins, GW471552 and GW471558, were studied in vivo for treatment of Pneumocystis carinii pneumonia. In the Wistar rat spontaneous pneumonia model, both azasordarins significantly reduced the number of P. carinii cysts per gram of lung homogenate when administered at 1 mg/kg of body we...

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Autors principals: Jimenez, Elena, Martínez, Antonio, Aliouat, El Moukhtar, Caballero, Jesus, Dei-Cas, Eduardo, Gargallo-Viola, Domingo
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC127331/
https://ncbi.nlm.nih.gov/pubmed/12121948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.8.2648-2650.2002
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