Therapeutic Efficacies of GW471552 and GW471558, Two New Azasordarin Derivatives, against Pneumocystosis in Two Immunosuppressed-Rat Models

Two new azasordarins, GW471552 and GW471558, were studied in vivo for treatment of Pneumocystis carinii pneumonia. In the Wistar rat spontaneous pneumonia model, both azasordarins significantly reduced the number of P. carinii cysts per gram of lung homogenate when administered at 1 mg/kg of body we...

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Argitaratua izan da:	Antimicrob Agents Chemother
Egile Nagusiak:	Jimenez, Elena, Martínez, Antonio, Aliouat, El Moukhtar, Caballero, Jesus, Dei-Cas, Eduardo, Gargallo-Viola, Domingo
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Microbiology (ASM) 2002
Gaiak:	Experimental Therapeutics
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127331/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12121948/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.8.2648-2650.2002
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