Therapeutic Efficacies of GW471552 and GW471558, Two New Azasordarin Derivatives, against Pneumocystosis in Two Immunosuppressed-Rat Models

Two new azasordarins, GW471552 and GW471558, were studied in vivo for treatment of Pneumocystis carinii pneumonia. In the Wistar rat spontaneous pneumonia model, both azasordarins significantly reduced the number of P. carinii cysts per gram of lung homogenate when administered at 1 mg/kg of body we...

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Bibliografiske detaljer
Main Authors: Jimenez, Elena, Martínez, Antonio, Aliouat, El Moukhtar, Caballero, Jesus, Dei-Cas, Eduardo, Gargallo-Viola, Domingo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC127331/
https://ncbi.nlm.nih.gov/pubmed/12121948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.8.2648-2650.2002
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