Small-Colony Mutants of Staphylococcus aureus Allow Selection of Gyrase-Mediated Resistance to Dual-Target Fluoroquinolones

Fluoroquinolones acting equally through DNA gyrase and topoisomerase IV in vivo are considered desirable in requiring two target mutations for emergence of resistant bacteria. To investigate this idea, we have studied the response of Staphylococcus aureus RN4220 to stepwise challenge with sparfloxac...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Pan, Xiao-Su, Hamlyn, Penelope J., Talens-Visconti, Raquel, Alovero, Fabiana L., Manzo, Ruben H., Fisher, L. Mark
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2002
Θέματα:
Mechanisms of Resistance
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC127329/
https://ncbi.nlm.nih.gov/pubmed/12121924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.8.2498-2506.2002
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