Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in Helicobacter pylori

Nitazoxanide (NTZ) is a redox-active nitrothiazolyl-salicylamide prodrug that kills Helicobacter pylori and also many anaerobic bacterial, protozoan, and helminthic species. Here we describe development and use of a spectrophotometric assay, based on nitroreduction of NTZ at 412 nm, to identify H. p...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Sisson, Gary, Goodwin, Avery, Raudonikiene, Ausra, Hughes, Nicky J., Mukhopadhyay, Asish K., Berg, Douglas E., Hoffman, Paul S.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2002
Schlagworte:	Mechanisms of Action: Physiological Effects
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127316/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12069963/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.7.2116-2123.2002
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