Enzymes Associated with Reductive Activation and Action of Nitazoxanide, Nitrofurans, and Metronidazole in Helicobacter pylori

Nitazoxanide (NTZ) is a redox-active nitrothiazolyl-salicylamide prodrug that kills Helicobacter pylori and also many anaerobic bacterial, protozoan, and helminthic species. Here we describe development and use of a spectrophotometric assay, based on nitroreduction of NTZ at 412 nm, to identify H. p...

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Detalhes bibliográficos
Main Authors: Sisson, Gary, Goodwin, Avery, Raudonikiene, Ausra, Hughes, Nicky J., Mukhopadhyay, Asish K., Berg, Douglas E., Hoffman, Paul S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC127316/
https://ncbi.nlm.nih.gov/pubmed/12069963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.7.2116-2123.2002
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