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Antitrypanosomal Activities of Proteasome Inhibitors

Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Nkemgu-Njinkeng, Joseph, Rosenkranz, Vera, Wink, Michael, Steverding, Dietmar
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2002
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127253/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12019136/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.6.2038-2040.2002
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