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Antitrypanosomal Activities of Proteasome Inhibitors

Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential o...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Principais autores: Nkemgu-Njinkeng, Joseph, Rosenkranz, Vera, Wink, Michael, Steverding, Dietmar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127253/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12019136/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.6.2038-2040.2002
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