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Antitrypanosomal Activities of Proteasome Inhibitors

Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential o...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Nkemgu-Njinkeng, Joseph, Rosenkranz, Vera, Wink, Michael, Steverding, Dietmar
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2002
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127253/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12019136/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.6.2038-2040.2002
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