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Antitrypanosomal Activities of Proteasome Inhibitors

Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential o...

Ausführliche Beschreibung

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Bibliografische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Nkemgu-Njinkeng, Joseph, Rosenkranz, Vera, Wink, Michael, Steverding, Dietmar
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2002
Schlagworte:
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127253/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12019136/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.6.2038-2040.2002
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