Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases

This work describes the discovery and characterization of a novel series of tricyclic natural product-derived metallo-β-lactamase inhibitors. Natural product screening of the Bacillus cereus II enzyme identified an extract from a strain of Chaetomium funicola with inhibitory activity against metallo...

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Main Authors: Payne, David J., Hueso-Rodríguez, Juan Antonio, Boyd, Helen, Concha, Néstor O., Janson, Cheryl A., Gilpin, Martin, Bateson, John H., Cheever, Christy, Niconovich, Nancy L., Pearson, Stewart, Rittenhouse, Stephen, Tew, David, Díez, Emilio, Pérez, Paloma, de la Fuente, Jesus, Rees, Michael, Rivera-Sagredo, Alfonso
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Chemistry; Biosynthesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC127244/
https://ncbi.nlm.nih.gov/pubmed/12019104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.6.1880-1886.2002
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