Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases

This work describes the discovery and characterization of a novel series of tricyclic natural product-derived metallo-β-lactamase inhibitors. Natural product screening of the Bacillus cereus II enzyme identified an extract from a strain of Chaetomium funicola with inhibitory activity against metallo...

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Autors principals: Payne, David J., Hueso-Rodríguez, Juan Antonio, Boyd, Helen, Concha, Néstor O., Janson, Cheryl A., Gilpin, Martin, Bateson, John H., Cheever, Christy, Niconovich, Nancy L., Pearson, Stewart, Rittenhouse, Stephen, Tew, David, Díez, Emilio, Pérez, Paloma, de la Fuente, Jesus, Rees, Michael, Rivera-Sagredo, Alfonso
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Chemistry; Biosynthesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC127244/
https://ncbi.nlm.nih.gov/pubmed/12019104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.6.1880-1886.2002
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