Pharmacodynamics of the New Fluoroquinolone Gatifloxacin in Murine Thigh and Lung Infection Models

Gatifloxacin is a new 8-methoxy fluoroquinolone with enhanced activity against gram-positive cocci. We used the neutropenic murine thigh infection model to characterize the time course of antimicrobial activity of gatifloxacin and determine which pharmacokinetic (PK)-pharmacodynamic (PD) parameter b...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Andes, D., Craig, W. A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Experimental Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127205/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12019073/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.6.1665-1670.2002
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