Single-Dose Pharmacokinetics of Amprenavir Coadministered with Grapefruit Juice

In this crossover study in 12 healthy volunteers, coadministration of amprenavir (1,200 mg; single dose) with grapefruit juice slightly reduced the maximum concentration of drug in serum (C(max)) compared to administration with water (7.11 versus 9.10 μg/ml), slightly increased the time to C(max) (1...

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Autores principales: Demarles, D., Gillotin, C., Bonaventure-Paci, S., Vincent, I., Fosse, S., Taburet, A. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC127190/
https://ncbi.nlm.nih.gov/pubmed/11959608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.5.1589-1590.2002
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