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A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised
The human cytomegalovirus-encoded glycoprotein US2 catalyzes proteasomal degradation of Class I major histocompatibility complex (MHC) heavy chains (HCs) through dislocation of the latter from the endoplasmic reticulum (ER) to the cytosol. During this process, the Class I MHC HCs are deglycosylated...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1271816/ https://ncbi.nlm.nih.gov/pubmed/14749736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600090 |
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