Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

The two iron regulatory proteins IRP1 and IRP2 bind to transcripts of ferritin, transferrin receptor and other target genes to control the expression of iron metabolism proteins at the post-transcriptional level. Here we compare the effects of genetic ablation of IRP1 to IRP2 in mice. IRP1−/− mice m...

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Huvudupphovsmän: Meyron-Holtz, Esther G, Ghosh, Manik C, Iwai, Kazuhiro, LaVaute, Timothy, Brazzolotto, Xavier, Berger, Urs V, Land, William, Ollivierre-Wilson, Hayden, Grinberg, Alex, Love, Paul, Rouault, Tracey A
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2004
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1271751/
https://ncbi.nlm.nih.gov/pubmed/14726953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600041
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