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An episomal mammalian replicon: sequence-independent binding of the origin recognition complex
An extrachromosomally replicating plasmid was used to investigate the specificity by which the origin recognition complex (ORC) interacts with DNA sequences in mammalian cells in vivo. We first showed that the plasmid pEPI-1 replicates semiconservatively in a once-per-cell-cycle manner and is stably...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1271667/ https://ncbi.nlm.nih.gov/pubmed/14685267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600029 |
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