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An episomal mammalian replicon: sequence-independent binding of the origin recognition complex
An extrachromosomally replicating plasmid was used to investigate the specificity by which the origin recognition complex (ORC) interacts with DNA sequences in mammalian cells in vivo. We first showed that the plasmid pEPI-1 replicates semiconservatively in a once-per-cell-cycle manner and is stably...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1271667/ https://ncbi.nlm.nih.gov/pubmed/14685267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600029 |
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