A Missense Mutation in the fabB (β-Ketoacyl-Acyl Carrier Protein Synthase I) Gene Confers Thiolactomycin Resistance to Escherichia coli

Thiolactomycin (TLM) is an antibiotic that inhibits bacterial type II fatty acid synthesis at the condensing enzyme step, and β-ketoacyl-acyl carrier protein synthase I (FabB) is the relevant target in Escherichia coli. TLM resistance is associated with the upregulation of efflux pumps. Therefore, a...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Jackowski, Suzanne, Zhang, Yong-Mei, Price, Allen C., White, Stephen W., Rock, Charles O.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127160/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11959552/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.5.1246-1252.2002
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