Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB.

Thiolactomycin (TLM) and cerulenin are antibiotics that block Escherichia coli growth by inhibiting fatty acid biosynthesis at the beta-ketoacyl-acyl carrier protein synthase I step. Both TLM and cerulenin trigger the accumulation of intracellular malonyl-coenzyme A coincident with growth inhibition...

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Bibliografische gegevens
Hoofdauteurs: Furukawa, H, Tsay, J T, Jackowski, S, Takamura, Y, Rock, C O
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1993
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC204787/
https://ncbi.nlm.nih.gov/pubmed/8509326
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