Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB.

Thiolactomycin (TLM) and cerulenin are antibiotics that block Escherichia coli growth by inhibiting fatty acid biosynthesis at the beta-ketoacyl-acyl carrier protein synthase I step. Both TLM and cerulenin trigger the accumulation of intracellular malonyl-coenzyme A coincident with growth inhibition...

詳細記述

書誌詳細

出版年:	J Bacteriol
主要な著者:	Furukawa, H, Tsay, J T, Jackowski, S, Takamura, Y, Rock, C O
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Microbiology (ASM) 1993
主題:	Research Article
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC204787/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8509326/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.175.12.3723-3729.1993
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