A Missense Mutation in the fabB (β-Ketoacyl-Acyl Carrier Protein Synthase I) Gene Confers Thiolactomycin Resistance to Escherichia coli

Thiolactomycin (TLM) is an antibiotic that inhibits bacterial type II fatty acid synthesis at the condensing enzyme step, and β-ketoacyl-acyl carrier protein synthase I (FabB) is the relevant target in Escherichia coli. TLM resistance is associated with the upregulation of efflux pumps. Therefore, a...

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Hlavní autoři: Jackowski, Suzanne, Zhang, Yong-Mei, Price, Allen C., White, Stephen W., Rock, Charles O.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2002
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC127160/
https://ncbi.nlm.nih.gov/pubmed/11959552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.5.1246-1252.2002
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